准教授
奥村 文彦
オクムラ フミヒコ
主要研究業績 - 2016年度以前
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Okumura F*, Uematsu K, Byrne SD, Hirano M, Joo-Okumura A, Nishikimi A, Shuin T, Fukui Y, Nakatsukasa K, Kamura T*(2016)
Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor alpha
Molecular and Cellular Biology, 36(12), 1803-1817, Co-corresponding author
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Uematsu K, Okumura F*, Tonogai S, Joo-Okumura A, Alemayehu DH, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T*(2016)
ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation
The Journal of Cell Biology, 215(1), 95-106, , Co-first and Co-corresponding author
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Okumura F*, Joo-Okumura A, Nakatsukasa K, Kamura T*(2016)
The role of cullin 5-containing ubiquitin ligases
Cell Division, 11, 1, Co-corresponding author
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Nakatsukasa, K.*, Okumura, F. & Kamura, T.*(2015)
Proteolytic regulation of metabolic enzymes by E3 ubiquitin ligase complexes: lessons from yeast
Critical Reviews in Biochemistry and Molecular Biology, 1-14.
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Nakatsukasa, K., Nishimura, T., Byrne, SD., Okamoto, M., Takahasi-Nakaguchi, A., Chibana, H., Okumura, F., Kamura, T.*(2015)
The Ubiquitin Ligase SCFUcc1 Acts as a Metabolic Switch for the Glyoxylate Cycle
Molecular Cell. 59, 22-34.
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Nakatsukasa, K., Kanada, A., Matsuzaki, M., Byrne, S. D., Okumura, F., and Kamura, T.*(2014)
The Nutrient Stress-Induced small GTPase Rab5 Contributes to the Activation of Vesicle Trafficking and Vacuolar Activity
Journal of Biological Chemistry. 289, 20970-20978.
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Yaguchi, H., Yabe, I., Takahashi, H., Okumura, F., Takeuchi, A., Horiuchi, K., Kano, T., Kanda, A., Saito, W., Matsumoto, M., Nakayama, K. I., Hatakeyama, S., and Sasaki, H*.(2014)
Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy
Journal of Neurology. 261, 224-6.
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Okumura F*, Okumura A, Nakatsukasa K, Kamura T*(2013)
Regulation of cellular functions by Elongin BC based E3 ubiquitin ligase
Seikagaku, 85(2), 76-88, Co-corresponding author
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Okumura F*, Okumura AJ, Uematsu K, Hatakeyama S, Zhang DE, Kamura T*(2013)
Activation of double-stranded RNA-activated protein kinase (PKR) by interferon-stimulated gene 15 (ISG15) modification down-regulates protein translation
Journal of Biological Chemistry, 288(4):2839-2847, Co-corresponding author
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Sato, T., Okumura, F., Ariga, T., and Hatakeyama, S.* (2012)
TRIM6 interacts with c-Myc and maintains pluripotency of mouse embryonal stem cells
Journal of Cell Science. 125(Pt 6), 1544-1555.
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Yaguchi, H., Okumura, F., Takahashi, H., Kano, T., Kameda, H., Uchigashima, M., Tanaka, S., Watanabe, M., Sasaki, H., and Hatakeyama, S.* (2012)
TRIM67 negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis
The Journal of Biological Chemistry. 287, 12050-12059.
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Okumura F*, Matsuzaki M, Nakatsukasa K, Kamura T*(2012)
The Role of Elongin BC-Containing Ubiquitin Ligases
Frontiers in Oncology, 2, 1-10, Co-corresponding author
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Sato, T., Okumura, F., Iguchi, A., Ariga, T., and Hatakeyama, S.*(2012)
TRIM32 promotes retinoic acid receptor alpha-mediated differentiation in human promyelogenous leukemic cell line HL60
Biochemical and Biophysical Research Communications. 417, 594-600.
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Sato, T., Okumura, F., Kano, S., Kondo, T., Ariga, T., and Hatakeyama, S.* (2011)
TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription
Journal of Cell Science. 124, 3492-502.
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Okumura F, Okumura AJ, Matsumoto M, Nakayama KI, Hatakeyama S*(2011)
TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells
Biochimica et Biophysica Acta, 1813(10), 1784-1792
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Noguchi, K., Okumura, F., Takahashi, N., Kataoka, A., Kamiyama, T., Todo, S., and Hatakeyama, S.*(2011)
TRIM40 promotes neddylation of IKK{gamma} and is downregulated in gastrointestinal cancers
Carcinogenesis. 32, 995-1004.
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Okumura F, Yoshida K, Liang F, Hatakeyama S*(2011)
MDA-9/syntenin interacts with ubiquitin via a novel ubiquitin-binding motif
Molecular and Cellular Biochemistry, 352(1-2), 163-172
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Bohgaki, M., Matsumoto, M., Atsumi, T., Kondo, T., Yasuda, S., Horita, T., Nakayama, K. I., Okumura, F., Hatakeyama, S., and Koike, T.*(2011)
14. Plasma gelsolin facilitates interaction between beta(2) glycoprotein I and alpha(5) beta(1) integrin
Journal of Cellular and Molecular Medicine. 15, 141-51.
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Shinada, K., Tsukiyama, T., Sho, T., Okumura, F., Asaka, M., and Hatakeyama, S.*(2011)
RNF43 interacts with NEDL1 and regulates p53-mediated transcription
Biochemical and Biophysical Research Communications. 404, 143-147.
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Okumura F, Kameda H, Ojima T, Hatakeyama S*(2010)
Expression of recombinant sea urchin cellulase SnEG54 using mammalian cell lines
Biochemical and Biophysical Research Communications, 395(3), 352-355
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Okumura F, Matsunaga Y, Katayama Y, Nakayama KI, Hatakeyama S*(2010)
TRIM8 modulates STAT3 activity through negative regulation of PIAS3
Journal of Cell Science, 123(Pt 13), 2238-2245
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Suizu, F., Hiramuki, Y., Okumura, F., Matsuda, M., Okumura, A. J., Hirata, N., Narita, M., Kohno, T., Yokota, J., Bohgaki, M., Obuse, C., Hatakeyama, S.,Obata, T., and Noguchi, M.*(2009)
10. The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt
Developmental Cell. 17, 800-10.
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Kikuchi, M., Okumura, F., Tsukiyama, T., Watanabe, M., Miyajima, N., Tanaka, J., Imamura, M., and Hatakeyam a, S.* (2009)
TRIM24 mediates ligand-dependent activation of androgen receptor and is repressed by a bromodomain-containing protein, BRD7, in prostate cancer cells
Biochimica et Biophysica Acta. 1793, 1828-1836.
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Maeda, H., Miyajima, N., Kano, S., Tsukiyama, T., Okumura, F., Fukuda, S., and Hatakeyama, S.*(2009)
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer/Molecular Cancer Research. 7, 1553-62.
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Okumura F.(2009)
Regulation of immune response by ubiquitin-like molecule ISG15
Seikagaku, 81(3), 223-232.
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Okumura F, Lenschow DJ, Zhang DE*(2008)
Nitrosylation of ISG15 prevents the disulfide bond-mediated dimerization of ISG15 and contributes to effective ISGylation.
Journal of Biological Chemistry, 283(36), 24484-24488
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Okumura, A. J., Peterson, L. F., Okumura, F., Boyapati, A., and Zhang, D. E.*(2008)
t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression/Blood. 112, 1392-1401.
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Okumura F, Zou W, Zhang DE*(2007)
ISG15 modification of the eIF4E cognate 4EHP enhances cap structure-binding activity of 4EHP
Genes & Development, 21(3), 255-260
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Okumura, A. J., Hatsuzawa, K., Tamura, T., Nagaya, H., Saeki, K., Okumura, F., Nagao, K., Nishikawa, M., Yoshimura, A., and Wada, I.*(2006)
Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system
Journal of Biological Chemistry. 281, 4495-4506.
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Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K., and Nakayama, K. I.*(2004)
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase
Nature Cell Biology. 6, 1229-35.
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Okumura F, Hatakeyama S, Matsumoto M, Kamura T, Nakayama KI*(2004)
Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis
Journal of Biological Chemistry, 279(51), 53533-53543
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Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K., and Nakayama, K. I.*(2004)
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
EMBO J. 23, 2116-25.
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