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Professor
Shun HAMADABrief personal historyProfessor, 2010-Present, Department of Nutrition and Health Science, Faculty of Human Environmental Science, Fukuoka Women's UniversityAssociate Professor, 2004-2010, Department of Nutrition and Health Science, Faculty of Human Environmental Science, Fukuoka Women's University Associate Professor, 2002-2004, KOKORO-Biology Laboratory, Graduate School of Frontier Biosciences, Osaka University Assistant Professor, 2000-2002, Division of Molecular Genetics, Institute for Molecular and Cellular Biology, Osaka University Assistant Professor, 1996-2000, Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba Education: 1992-1998 Ph.D., in Neuroanatomy, Univerisity of Tsukuba, 1998 1985-1992 M.D., School of Medicine, University of Tsukuba, 1992 DegreesM.D., Ph. D.Research themesMechanisms of brain damage induced by thiamine (vitamin B1) deficiencyEarly evolution of synapses and neuronal circuits Select publication list1.Hamada, S., Hirashima, H., Imaeda, M., Okamoto, M., Hamaguchi-Hamada, K., Kurumata-Shigeto, M. Thiamine deficiency induces massive cell death in the olfactory bulbs of mice. J. Neuropathol. Exp. Neurol. 72(12), 1193-1202, 2013 2.Hasegawa S., Hirabayashi T., Kondo T., Inoue K., Esumi S., Okayama A., Hamada S., Yagi T. Constitutively expressed protocadherin-a regulates the coalescence and elimination of homotypic olfactory axons through its cytoplasmic reion. Front. Mol. Neurosci.5:97, 2012 3.Ohsawa S., Hamada S., Kuida K., Yoshida H., Igaki T., Miura M. Maturation of the olfactory sensory neurons by Apaf-1/caspase-9-mediated caspase activity. Proc. Natl. Acad. Sci. USA 107(30), 13366-71, 2010. 4.Ohsawa S., Hamada S., Asou H., Kuida K., Uchiyama Y., Yoshida H., Miura M. Caspase-9 activation revealed by Semaphorin 7A cleavage is independent of apoptosis in the aged olfactory bulb. J. Neurosci. 29(36), 11385-11392, 2009. 5.Katori S., Hamada S. (co-first author), Noguchi Y., Fukuda E., Yamamoto T., Yamamoto H., Hasegawa S., Yagi T. Protocadherin-a family is required for serotonergic projections of appropriately innervate target brain areas. J. Neurosci. 29(29), 9137-9147, 2009. 6.Hamaguchi-Hamada K., Fujisawa Y., Koizumi O., Muneoka Y., Okado N., Hamada S. Immunohistochemical evidence for the existence of novel mammalian neuropeptides related to hydra GLW-amide neuropeptide family. Cell Tissue Res. 337(1), 15-25, 2009. 7.Hattori K., Fukuzako H., Hashiguchi T., Hamada S., Murata Y., Isosaka T., Yuasa S., Yagi T. Decreased expression of Fyn protein and disbalanced alternative splicing patterns in platelets from patients with schizophrenia. Psychiatry Res. 168(2), 119-128, 2009. 8.Fukuda E., Hamada S., Hasegawa S., Katori S., Sanbo M., Miyakawa T., Yamamoto T., Yamamoto H., Hirabayashi T., Yagi T. Down-regulation of protocadherin-a A isoforms in mice changes contextual fear conditioning and spatial working memory. Eur. J. Neurosci. 28(7), 1362-1376, 2008. 9.Ohsawa S., Hamada S., Yoshida H., Miura M. Caspase-mediated changes in histone H1 in early apoptosis: prolonged caspase activation in developing olfactory sensory neurons. Cell Death & Diff. 15(9), 1429-1439, 2008. 10.Hasegawa S., Hamada, S.(co-first author), Kumode, Y., Katori, S., Fukuda, E., Uchiyama, Y., Hirabayashi, T., Mombaerts, P., Yagi, T. The protocadherin-a family is involved in axonal coalescence of olfactory sensory neurons into glomeruli of the olfactory bulb in mouse. Mol. Cell Neurosci. 38, 66-79, 2008. 11.Osada T., Tamamaki N., Song S.Y., Kakazu N., Yamazaki Y., Makino H., Sasaki A., Hirayama T., Hamada S., Nave K.A., Yanagimachi R., Yagi T. Developmental pluripotency of the nuclei of neurons in the cerebral cortex of juvenile mice. J. Neurosci. 25(37), 8368-8374, 2005 12.Makino H., Yamazaki Y., Hirabayashi T., Kaneko R., Hamada S., Osada T., Kawamura Y., Yanagimachi R., Yagi T. Mouse embryos and chimera cloned from neural cells in the postnatal cerebral cortex. Cloning Stem Cells 7(1), 45-61, 2005. 13.Esumi S., Kakazu N., Taguchi Y., Hirayama T., Sasaki A., Hirabayashi T., Koide T., Kitsukawa T., Hamada S., Yagi T. Monoallelic yet combinatorial expression of variable exons of the CNR/Protocadherin- gene cluster in single neurons. Nature Genetics 37(2), 171-176, 2005. 14.Ohsawa S., Hamada S., Kakinuma Y., Yagi T., Miura M. A novel function of neuronal PAS domain protein 1 (NPAS1) in erythropoietin expression in neuronal cells. J. Neurosci. Res. 79(4), 451-458, 2005. 15.Morishita H., Kawaguchi M., Murata Y., Seiwa C., Hamada S., Asou H., Yagi T. Myelination triggers down-regulation of axonal CNR/Protocadherin family expression. Eur. J. Neurosci. 20(11), 2843-2847, 2004. 16.Morishita H., Murata Y., Esumi S., Hamada S., Yagi T. CNR/Pcdhα family in subplate neurons, and developing cortical connectivity. Neuroreport 15(17), 2595-2599, 2004. 17.Murata Y., Hamada S., Morishita, H., Mutoh T., Yagi T. Interaction with Protocadherin-gamma regulates the cell-surface expression of Protocadherin-alpha. J. Biol. Chem. 279, 49508-49516, 2004. 18.Hamaguchi-Hamada K., Hamada S., Yagi T. Exposure to hexanal odor induces extraordinary Fos expression in the medial preoptic area and amygdala of Fyn tyrosine kinase-deficient mice. Mol. Brain Res. 130 187-190. 2004. 19.Hamaguchi-Hamada K., Sanbo C., Hamada S., Yagi T. Exposure to hexanal odor influences maternal behavior and induces neonatal death in Fyn tyrosine kinase-deficient mice. Neurosci. Res. 48(3) 259-67. 2004. 20.Sugino H., Yanase H., Hamada S., Kurokawa K., Asakawa S., Shimizu N., Yagi T. Distinct genomic sequence of the CNR/Pcdhalpha genes in chicken. Biochem. Biophys. Res. Commun. 316(2) 437-45. 2004 21.MutohT., Hamada S., Senzaki K., Murata Y., Yagi T. Cadherin-related neuronal receptor 1 (CNR1) has cell adhesion activity with β1 integrin mediated through the RGD site of CNR1. Exp. Cell Res. 294(2) 494-508. 2004 22.Yagi T., Tada M., Tanaka Y., Senzaki K., Hirayama T., Hamada S., Sugino H. Diversity of the cadherin-related neuronal receptor family in the nervous system. Int. Congress Series 1246 127-136. 2002 23.Yamazaki Y., Makino H., Hamaguchi-Hamada K., Hamada S., Sugino H., Kawase E., Miyata T., Ogawa M., Yanagimachi R., Yagi T. Assessment of the developmental totipotency of neural cells in the cerebral cortex of mouse embryo by nuclear transfer. Proc. Natl. Acad. Sci. USA 98(24) 14022-6. 2001 24.Hamada S., Yagi T. The cadherin-related neuronal receptor (CNR) family: a novel diversified cadherin family at the synapse. Neurosci. Res. 41(3). 207-215. 2001 25.Takei Y., Hamada S., Senzaki K., Mutoh T., Sugino H., Yagi T. Two Novel CNRs from the CNR gene cluster have molecular features distinct from those of CNR1-8. Genomics 72 321-330. 2001 26.Maxishima M., Shiga T., Shutoh F., Hamada S., Maeshima T., Okado N. 27.Serotonin 2A receptor-like immunoreactivity is detected in astrocytes but not in oligodendrocytes of rat spinal cord. Brain Res. 889(1-2). 270-273. 2001 28.Shutoh F., Hamada S., Shibata M., Narita M., Shiga T., Azmitia E. C., Okado N. Long term depletion of serotonin leads to selective changes in glutamate receptor subunits. Neurosci. Res. 38(4) 365-371. 2000 29.Sugino H., Hamada S. (co-first author), Yasuda R., Tuji A., Matsuda Y., Fujita M., Yagi T. Genomic organization of the family of CNR cadherin genes in mice and human. Genomics 63(1). 75-87. 2000 30.Kohmura N., Senzaki K., Hamada S., Kai N., Yasuda R., Watanabe M., Ishii H., Yasuda M., Mishina M., Yagi T. Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex. Neuron 20. 1137-1151. 1998 31.Maeshima T., Shutoh F., Hamada S. (corresponding author), Senzaki K., Hamaguchi-Hamada K., Ito R., Okado N. Serotonin2A receptor-like immunoreactivity in rat cerebellar Purkinje cells. Neurosci. Lett. 252(1). 72-74. 1998 32.Maeshima T., Ito R., Hamada S., Senzaki K., Hamaguchi-Hamada K., Shutoh F., Okado N. The cellular localization of 5-HT2A receptors in the spinal cord and spinal ganglia of the adult rat. Brain Res. 797(1). 118-124. 1998 33.Hamada S., Senzaki K., Hamaguchi-Hamada K., Tabuchi K., Yamamoto T., Yoshikawa S., Okano H., Okado N. Localization of 5-HT2A receptor in rat cerebral cortex and olfactory system revealed by immunohistochemistry using two antibodies raised in rabbit and chicken. Mol. Brain Res. 54(2). 199-211. 1998 34.Chen L., Hamaguchi K., Hamada S., Okado N. Regional differences of serotonin-mediated synaptic plasticity in the chicken spinal cord with development and aging. J. Neural Transplant. Plast. 6. 41-48. 1997 35.Niitsu Y., Hamada S.(co-first author), Hamaguchi K., Mikuni M., Okado N. Regulation of synapse density by 5-HT2A receptor agonist and antagonist in the spinal cord of chicken embryo. Neurosci. Lett. 195. 159-162. 1995 36.Hamada S., Ogawa M., Okado N. Immunohistochemical examination of intraspinal serotonin neurons and fibers in the chicken lumbar spinal cord and coexistence with leu-enkephalin. Cell Tissue Res. 282. 387-397. 1995 37.Chen L., Hamaguchi K., Ogawa, M., Hamada S., Okado N. PCPA reduces both monoaminergic afferents and nonmonoaminergic synapses in the cerebral cortex. Neurosci Res. 19. 111-115. 1994 38.Okado N., Cheng L., Tanatsugu Y., Hamada S., Hamaguchi K. Synaptic loss following removal serotonergic fibers in newly hatched and adult chickens. J Neurobiol. 24. 687-698. 1993 39.Okado N., Matsukawa M., Noritake S., Ozaki S., Hamada S., Arita M., Kudo N. Species differences in the distribution and coexistence ratio of serotonin and substance P in the monkey, cat, rat and chick spinal cord. Neurosci. Lett. 132(2). 155-158. 1991 Research fieldEvolutionary NeuroscienceNutritional Neuroscience Membership of Academic SocietiesThe Japanese Association of AnatomistsJapan Neuroscience Society The Vitamin Society of Japan Related field
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